Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease
Jurrien ten Berg, Dirk Sibbing, Bianca Rocca, Eric Van Belle, Bernard Chevalier, Jean-Philippe Collet, Dariusz Dudek, Martine Gilard, Diana A Gorog, Julia Grapsa, Erik Lerkevang Grove, Patrizio Lancellotti, Anna Sonia Petronio, Andrea Rubboli, Lucia Torracca, Gemma Vilahur, Adam Witkowski, Julinda Mehilli
European Heart Journal, Volume 42, Issue 23, 14 June 2021, Pages 2265–2269
Abstract
Transcatheter aortic valve implantation (TAVI) is effective in older patients with symptomatic severe aortic stenosis, while the indication has recently broadened to younger patients at lower risk. Although thromboembolic and bleeding complications after TAVI have decreased over time, such adverse events are still common. The recommendations of the latest 2017 ESC/EACTS Guidelines for the management of valvular heart disease on antithrombotic therapy in patients undergoing TAVI are mostly based on expert opinion. Based on recent studies and randomized controlled trials, this viewpoint document provides updated therapeutic insights in antithrombotic treatment during and after TAVI.
Antithrombotic treatment during and after transcatheter aortic valve implantation. The figure summarizes the consensus for treating patients who are candidate for transcatheter aortic valve implantation, according to the presence or absence of oral anticoagulation indications and to recent coronary stenting. ACT, activated clotting time; ASA, aspirin; DAPT, dual antiplatelet therapy; HIT heparin-induced thrombocytopenia; NOAC, non-vitamin-K antagonist oral anticoagulant; OAC, oral anticoagulation; SAPT, single antiplatelet therapy; TAVI, transcatheter aortic valve implantation; VKA, vitamin K antagonist. *Low-dose aspirin or clopidogrel. #Bivalirudin if heparin-induced thrombocytopenia. @Duration according to bleeding risk.