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Introducing Cutaneous Miscellaneous Boards Booster. Each episode will feature high-yield board review questions pertaining to the board review topic discussed. Questions and answer explanations are written and edited by current dermatology residents/fellows and are sourced from key resources such as Bolognia Dermatology, Andrews’ Dermatology and Alikhan’s Review of Dermatology.

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* 1. Epidermolysis bullosa simplex is caused by mutation(s) in which of the following gene(s)?

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* A 17-year-old boy who has had blistering since birth has now started to develop muscle weakness and scarring hair loss. A mutation in which of the following is likely responsible for his condition?

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* Electron microscopy is the gold standard for the diagnosis of EB through ultrastructural evaluation of the cleavage plane of a fresh induced blister. What is the preferred fixative for electron microscopy?

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* Junctional epidermolysis bullosa is caused by fragility and separation of the skin causing blisters at what layer/component?

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* A young patient presents with a history of generalized blisters that cause significant scarring and milia after healing. This patient has a high risk of developing what condition at an earlier age that usual?

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